OUR APPROACH
Corami™ is developing an integrated system that delivers therapeutics directly to the heart. The Corami™ Depot is composed of a PEG-based hydrogel containing the therapeutic payload. The Corami™ Depot is delivered to the intrapericardial space with proprietary delivery devices for open-chest and minimally invasive surgeries.
Establishing the intrapericardial route with an integrated system
The Corami™ Way
We are developing a robust system for implementing a wide range of therapeutic modalities into our Corami™ Depot for cardiac indications. To address the unmet physiological needs, we must intentionally optimize engineering design factors to overcome the challenges of cardiac therapeutic delivery.
OUR SOLUTION
Corami™ for Minimally Invasive Applications
We are taking our system forward with two strategic programs.
Not to scale, for illustration purposes.
POC: Proof-of-Concept
Scientific Evidence
*Preclinical data on file. Results may not be predictive of clinical outcomes.
Garcia, J.R., et al.
A Minimally Invasive, Translational Method to Deliver Hydrogels to the Heart Through the Pericardial Space
JACC: Basic to Translational Science. 2017; 2(5): 601-609.
Garcia, J.R., et al.
Minimally Invasive Delivery of Hydrogel-Encapsulated Amiodarone to the Epicardium Reduces Atrial Fibrillation
Circulation: Arrhythmia and Electrophysiology. 2019; 11(5): e006408.
